Among the 12 biomarkers associated with breast cancer risk, higher baseline circulating concentrations of CRP (HR for the highest quartile = 1.75, 95 % CI = 1.34–2.29, Ptrend <0.001) and IGF-1 (HR for the highest quartile = 1.31, 95 % CI = 1.04–1.66, Ptrend = 0.030) were also positively associated with breast cancer mortality risk, even after adjusting for other potential risk factors for breast cancer (Table 2, Supplementary Table 9). This evidence concerns the gene IGF1 and breast cancer.