Among the 12 biomarkers associated with breast cancer risk, higher baseline circulating concentrations of CRP (HR for the highest quartile = 1.75, 95 % CI = 1.34–2.29, Ptrend <0.001) and IGF-1 (HR for the highest quartile = 1.31, 95 % CI = 1.04–1.66, Ptrend = 0.030) were also positively associated with breast cancer mortality risk, even after adjusting for other potential risk factors for breast cancer (Table 2, Supplementary Table 9). Here, IGF1 is linked to breast carcinoma.