CRP and breast carcinoma: Among the 12 biomarkers associated with breast cancer risk, higher baseline circulating concentrations of CRP (HR for the highest quartile = 1.75, 95 % CI = 1.34–2.29, Ptrend <0.001) and IGF-1 (HR for the highest quartile = 1.31, 95 % CI = 1.04–1.66, Ptrend = 0.030) were also positively associated with breast cancer mortality risk, even after adjusting for other potential risk factors for breast cancer (Table 2, Supplementary Table 9).