After adjusting for age, sex, APOE ɛ4 status, MMSE score, and AD CSF biomarkers, higher CSF levels of cholesteryl ester CE(11D3:1) (p = 0.01) and an unknown lipid (mass 528.4519, RT 8.59) (p = 0.048) were associated with a significantly greater risk of MCI to AD progression (Table 4). Here, APOE is linked to Alzheimer disease.