PPARGC1A and amyotrophic lateral sclerosis: Surprisingly, overexpression of peroxisome proliferator-activated receptor gamma coactive 1-alpha (PGC-1α), known to regulate muscle fibre types and their response to metabolic demands while increasing the oxidative capacity of myotubes and fatigue resistance, did not affect the onset of ALS signs or alter the survival of transgenic mice (Da Cruz et al. 2012).