GRIA2 and amyotrophic lateral sclerosis: Although the total transcript level of GluR2 in the spinal cord of ALS patients is comparable to that in healthy, post-translational editing fails in almost half of all transcripts, leading to an increase in the level of Ca2+-permeable AMPAR with enhanced AMPAR-mediated Ca2+ currents (Kwak and Kawahara 2005).