For instance, cytoplasmic aggregations of TDP-43 DNA/RNA binding protein observed in TDP-43 mice, which represent the hallmark of degenerating human MNs, are not observed in SOD1 and FUS (fused in sarcoma) mouse models (Vance et al. 2009; Mackenzie et al. 2007). This evidence concerns the gene TARDBP and sarcoma.