Overexpression of ephrin receptor A4 (EPHA4) in MNs, on the other hand, impairs the reinnervation of NMJs (Van Hoecke et al. 2012) with EPHA4 level changes in the blood of patients correlating with the onset of clinical ALS (Van Hoecke et al. 2012). This evidence concerns the gene EPHA4 and amyotrophic lateral sclerosis.