TFE3 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: FISH using break-apart probes for TFE3 has been the gold standard for diagnosis but similar to TFEB-tRCC, small intrachromosomal gene inversions such as RBM10::TFE3, GRIPAP1::TFE3, RBMX::TFE3, and NONO::TFE3 are impossible to detect by this test [53, 108].