TFE3 and Renal neoplasm: Based on similar morphologies, immunohistochemical profiles and related molecular pathologies TFEB-rearranged renal neoplasms were initially grouped together with transcription factor binding to IGHM enhancer 3 (TFE3)-rearranged RCCs into the microphthalmia-associated transcription factor (MiT) family translocation carcinoma subtype in the 2016 WHO classification [51].