Our recent study demonstrated that FGF1ΔHBS, a non-mitogenic variant of native FGF1, prevented high fat and high cholesterol (HFHC) diet-induced nonalcoholic steatohepatitis (NASH) in ApoE knockout (ApoE-KO) mice and reversed the established NAFLD in late stage db/db type 2 diabetic mice [21]. This evidence concerns the gene APOE and metabolic dysfunction-associated steatohepatitis.