In support of this notion, our recent study indicated that replenishment of recombinant FGF1△HBS protein mitigated the elevation of plasma ALT and ALT in type 2 diabetic mice [21]; a more direct evidence from a recent study indicated that replenishment of recombinant FGF1 protein alone or in combination with resveratrol almost completely normalized plasma ALT and AST in DOX-treated mice [27]. This evidence concerns the gene GPT and type 2 diabetes mellitus.