INS and Hypoglycemia: It should be noted that on Day 2 of the case study, glucose levels hovered just below 3.9 mmol/L between 12:00 and 5:00 a.m. While this may have been caused by poorly dosed insulin adjustments (i.e., 55% TBR, 1:16 ICR, 3.4 CF) on Day 1 or other uncontrolled variables, we suspect that overcompensating for high BG (i.e., ~12 mmol/L) between 7:30 and 9:00 p.m. on Day 1 (Figure 1) may have resulted in hypoglycemia during the early hours of Day 2.