PIEZO1 and channelopathy: Correspondingly, it was put forward that Piezo2 channelopathy-derived subthreshold-imbalanced Ca2+ currents could induce NMDA activation, and the activated NMDA receptors could have a central signaling role in this functional crosstalk during the aforementioned transient autonomic disbalance, not to mention that Piezo1–Piezo2 crosstalk might have additional importance in this process [4].