TNF and serum lipopolysaccharide activity: The natural and recombinant anti-LPS factor Limulus (ALF-L) also suppressed endotoxin-mediated activation of cultured endothelial and B cells, reduced the concentration of endotoxin and TNF-α in the blood serum of experimental animals, and protected them from death in the late stages of endotoxemia and sepsis [10,11,12,13,14].