C16 acid (1) and its derivatives 7(E)-9-keto-octadec-7-enoic acid (C18 acid) and 7(E)-9-keto-octadec-7-enamide (C18 amide) from Ulva lactuca demonstrated Nrf2/ARE activity in IMR-32 human neuroblastoma, a widely used cellular model for oxidative stress, with the highest ARE activation induced by the C18 acid derivative of 1 with no observed effects on viability [14]. This evidence concerns the gene NFE2L2 and neuroblastoma.