Other metabolic alterations include the production of the onco-metabolite 2-hydroxyglutarate (2-HG) as a result of a point mutation in the isocitrate dehydrogenase 1/2 (IDH1/2) gene, strongly associated with a discrete subset of brain cancers (IDH-mutant gliomas) [3,4,5]. Here, IDH1 is linked to glioma.