It could be reasonable to think that, unlike acute insults, such as acute or fulminant hepatitis, where FGF-21 peaks at high levels [29], in the setting of a chronic infection, FGF-21 manifests an initial peak followed by a persistent, moderate increase as a state of FGF-21 resistance progressively develops [45,46]. Here, FGF21 is linked to Fulminant hepatitis.