A systematic review and network meta-analysis conducted by Pan X et al. concluded that increased concentrations of several chemokines such as CCL2, CCL4, CCL20, CXCL8, and CXCL10 could be associated with the presence of NAFLD [71], although further research is required to establish the potential place of chemokines in the diagnostic biomarker panel for NAFLD and NASH. This evidence concerns the gene CCL2 and metabolic dysfunction-associated steatotic liver disease.