THBS2 and metabolic dysfunction-associated steatotic liver disease: Thrombospondin 2 (TSP2) has various functions including collagen formation, and Kimura et al. analyzed the relation between NAFLD and serum TSP2 levels, resulting in an AUROC of 0.82 for predicting severe fibrosis [35], while in the evaluation conducted by Kozumi et al., an AUROC of 0.856 for predicting advanced fibrosis was obtained [36].