With regards to brain evaluation, based on the incidence of brain metastases in ALK-positive NSCLC, as well as knowing the CNS activity of ALK TKIs, all faculty members agreed that brain magnetic resonance imaging (MRI) with gadolinium is the recommended radiological exam for brain evaluation, both at baseline and at periodic assessments during oncological treatment [30,31]. The gene discussed is ALK; the disease is non-small cell lung carcinoma.