SMO and nevoid basal cell carcinoma syndrome: However, this cancer arose in a patient known for nevoid basal cell carcinoma syndrome, which is an autosomal-dominant inherited disorder in which patients develop multiple BCCs earlier than the general population due to a variety of mutations in the Sonic hedgehog pathway, namely, in the genes PTCH1, SMO, PTCH2, and SUFU [75,76,77].