PDCD1 and hepatocellular carcinoma: One such trial, NCT03753659, is a multicenter, single-arm, prospective, open-label phase II study examining the clinical efficacy of peri-interventional treatment using the anti-PD-1 antibody pembrolizumab in HCC patients eligible for local ablation via various methods such as RFA, MWA, brachytherapy, or a combination of TACE with RFA, MWA, or brachytherapy [122].