PDCD1 and hepatocellular carcinoma: Although this study focused on markers in lung adenocarcinoma, an immunohistochemical study was performed that analyzed the expression of PD-1 and TIM-3 in HBV-associated HCC compared to HBV-induced liver cirrhosis, and it found elevated expression of TIM-3 in the HCC tissues over the cirrhosis tissues (p < 0.001) [127].