Our results suggest that the prognosis of CRC patients with a positive expression of PD-L1 in TC is better than the negative, which may partly be attributed to the positive expression of PD-L1 in TC being more likely to occur in dMMR as well as the positive expression of PD-L1 in IC significantly correlating to the early TNM stage. The gene discussed is CD274; the disease is colorectal carcinoma.