A founder effect in Newfoundland and Labrador has been identified in the prevalence of several malignancy-associated Mendelian disorders such as MEN1 (multiple endocrine neoplasia type 1) and HNPCC (hereditary non-polyposis colorectal cancer, also known as Lynch Syndrome) [19]. The gene discussed is MEN1; the disease is multiple endocrine neoplasia type 1.