CD274 and cancer: It is important to note that the period of ATB medication (Figure 1) with respect to ICIs and the class of ATBs given [93,94], duration of the exposure [95], and route of administration [96], apart from the type of ICI [97], host PD-L-1 expression [59,98], and stage of cancer (Figure 2), all seem to have an important role in the overall clinical success.