In vivo decrease in blood glucose levels, accelerated skin wounds’ re-epithelization in diabetic rats by inhibiting the inflammatory cell infiltration, decreasing IL1-β, IL-6, TNF-α expression, and reducing oxidative stress, down-regulated NF-kB and up-regulated SOD1 and glutathione peroxidase (GSH-Px) expression mediated by p-Nrf2;In vivo intraperitoneal administration treated diabetes-associated wounds by targeting NF-kB/MMP-9 axis and Nrf2-mediated antioxidant system. This evidence concerns the gene NFE2L2 and diabetes mellitus.