IRF4 and cryptococcosis: Furthermore, mice deficient in cDC2s, abrogated using CD11c-cre IRF4 fl/fl mice, experienced blunted Th2 cell accumulation with cryptococcal infection [93], while BATF3−/− (a knockout of cDC1s [94]), and CCR2−/− (a knockout of monocytes and MoDCs) [95] mice replaced protective Th1 with robust Th2 responses during cryptococcal infection [27,93].