MAPK3 and Autoimmunity: Research has demonstrated that MAPK1 can mediate the growth and differentiation of T and B cells; improving the body’s immune capacity by regulating humoral and cellular immunity MAPK3 is essential for inducing T cells and has influence on dendritic cells (DCs, which are professional antigen presenting cells that instruct T cells during the inflammatory course of experimental autoimmune encephalomyelitis), arming T cells in autoimmunity [32].