HIF1A also competes against MYC for binding to SP1, a coactivator of MYC, at the promoters of MYC target genes such as MutS homolog 2 (MSH2), MSH6, and nibirin, which encode DNA repair proteins, in human HCT116 colorectal carcinoma cell line [107,108] and the E-type prostanoid receptor in human HCA-7 colon cancer cell line [109]. Here, MSH2 is linked to colorectal carcinoma.