For instance, HIF1A displaces MYC binding from the promoter of cyclin-dependent kinase inhibitor 1A (CDKN1A, p21cip1) and upregulates the expression of p21 (CDKN1A) in human HCT116 colorectal carcinoma cell line [106]. The gene discussed is CDKN1A; the disease is colorectal carcinoma.