HIF-1, SP1, and MYC, which function as master regulators of cancer, interact with each other and modulate the expression of many genes whose functions are associated with the development and maintenance of cancer, such as the genes involved in the regulation of proliferation, CSCs, metabolism, angiogenesis, stress response, and metastasis (as described in Section 1 and Section 2). This evidence concerns the gene SP1 and cancer.