SP1 promotes tumor angiogenesis via activation of vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), and VEGF receptor 3 (VEGFR3) [65,66,67], whereas HIF-1 is a master regulator of angiogenesis, participating in vasculature formation by synergistic correlations with other proangiogenic factors such as VEGF, placental growth factor, and angiopoietins [68]. Here, FLT4 is linked to neoplasm.