Malik et al. [3] discovered, using a statistical method called CoMEx (Combined score of DNA Methylation and Expression) to assess differentially expressed and methylated genes/microRNAs (miRNAs) between human seminoma and normal tissues, two hub miRNAs (miR-182-5p and miR-338-3p), five hub TFs (ETS1, HIF1A, hepatocyte nuclear factor-1 alpha, MYC, and SP1), and three hub genes (cadherin 1, C-X-C chemokine receptor type 4, and Snail family transcriptional repressor 1) in the seminoma-specific regulatory network. This evidence concerns the gene SP1 and seminoma.