Wilson and Volker Filipp investigated complementary omics in human cancer, and discovered a close teamwork of transcriptional and epigenomic machinery, which is tightly connected and comprises histone lysine demethylase 3A, basic helix-loop-helix factors, MYC, hypoxia-inducible factor 1 alpha (HIF1A), and sterol regulatory element-binding transcription factor 1, as well as differentiation factors such as activator protein 1, myogenic differentiation 1, specificity protein 1 (SP1), Meis homeobox 1, zinc finger E-box-binding homeobox 1, and ETS like-1 protein (ETS1) [1]. The gene discussed is HIF1A; the disease is cancer.