VHL and kidney cancer: Meanwhile, under hypoxia, HIF-1 can induce MAX interactor 1, dimerization protein, which inhibits the transcriptional activity of MYC by competing for MAX and represses MYC target genes [103] such as peroxisome proliferator-activated receptor gamma coactivator 1-beta in human pVHL-null kidney cancer cell lines [104] or ornithine decarboxylase in multiple human cancer cell lines [105].