Free fatty acids along with cytokines and adipokines contribute to insulin resistance in the liver via the activation of numerous signaling pathways including the inhibitor of κB-kinase-β (Iκκβ), c-Jun N-terminal kinase (JNK), protein kinase C, and protein tyrosine phosphatase 1b (PTP1b). This evidence concerns the gene PTPN1 and Insulin resistance.