In a mouse model of MASLD induced by deficiency of methionine and choline, without obesity and peripheral fat accumulation, liver histology showed increased inflammatory infiltrates [90], followed by increased expression of proinflammatory cytokines IL-6 and TNF, while anti-inflammatory IL-10 expression was decreased [91,92]. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.