EZH2 and lymphoma: The distribution of chromatin states for both EZH1 and EZH2 play a significant role in the global regulation of histone methylation in aggressive lymphomas; thus, it is essential to inhibit them to achieve a good outcome in EZH2 overexpression or EZH2 mutations in histone-modifying genes as well as in precancerous cells that are affected by epigenetic disruptions [116].