In conclusion, we revealed that TWEAK and TGF-β1 stimulation and an OVA-induced asthma murine model upregulates MAP3K19 mRNA expression; MAP3K19 suppresses TWEAK-stimulated airway epithelial responses, including adhesion molecule attenuation and RANTES production; and it suppresses allergic airway inflammation in a mouse model of asthma, suggesting that MAP3K19 regulates allergic airway inflammation in patients with asthma. Here, MAP3K19 is linked to asthma.