However, studies on the cell culture model and asthma murine model have suggested that MAP3K19 is involved in TWEAK, TGF-β1, and their combination, which induced E-cadherin reduction, the production of RANTES, ERK phosphorylation, MKP-1 expression, and the OVA-induced asthma model pathology, including RANTES production. This evidence concerns the gene CCL5 and asthma.