In hepatocellular carcinoma, MIR4435-2HG sequesters miR-1-3p, miR-125b-5p, miR-22-3p, miR-513a-5p and miR-136-5p, upregulating downstream target genes such as MM9, SRY-Box transcription factor 12 (SOX12), Ribonucleotide reductase M1/2 subunit (RRM1/2), Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ), Kruppel like factor 5 (KLF5), and B3GNT, thereby promoting hepatocellular carcinoma progression [13,27,28,52,104,105,106,107]. The gene discussed is KLF5; the disease is hepatocellular carcinoma.