MIR4435-2HG is present in exosomes, and these exosomes activate the Jagged1 (JAG1)/Notch pathway and Janus kinase 1 (JAK1)/signal transducer and activator of transcription 3 (STAT3) pathway, promoting the polarization of M2 macrophages, enhancing the EMT process, and migration of gastric cancer cells [25,111]. Here, STAT3 is linked to gastric cancer.