A study by Andrade IGA et al. showed a greater incidence of high levels of ultrasensitive C-reactive protein (CRP), reduced amount selenium in plasma and glutathione peroxidase (GPX) activity, elevated oxidized LDL fraction, and decreased levels of Apo-A-1 in CVID patients compared to the control group, suggesting oxidative stress and increased cardiovascular risk [16]. This evidence concerns the gene CRP and common variable immunodeficiency.