Compounds interconnecting the inflammatory pathogenesis of the SS glandular infiltration and the inflammatory component of the atherosclerotic lesion of the arterial wall also include a complex, consisting of the purinergic P2x7 receptor (P2X7R) and inflammasome NLRP3, which is involved in the pathogenesis of focal inflammation in SS through caspase-1-mediated release of IL-18 [62]. The gene discussed is CASP1; the disease is synovial sarcoma.