KRAS and glioblastoma: Suppressing autophagy has shown promise in inhibiting glioblastoma development; for instance, the knockdown of key autophagy-related genes, such as Atg7, Atg13, or Ulk1, disrupts autophagy and inhibits glioblastoma development in KRAS-driven glioblastoma mouse models [63], indicating the critical role of autophagy in tumor initiation.