CASP1 and Alzheimer disease: An interesting study supporting the role of microglia in the clearance of Aβ plaques reports that the inflammasome components NLRP3 and caspase-1 colocalize with p-Tau and Aβ in glial cells, as well as the produced cytokines IL-1β and IL-18, which are more highly expressed in the temporal cortex of the post-mortem AD brain [114,121].