In this context, the systematic review developed by Gkantzios et al. [103] emphasizes the potential of a combined panel BNP, glial GFAP, MMP-9, and AQP4 proteins along with the red cell distribution width (RDW) and the neutrophil-to-lymphocyte ratio (NLR) clinical parameters as a valuable prospect for enhancing stroke diagnostic strategies in the future. Here, AQP4 is linked to stroke disorder.