All 24 well-differentiated liposarcomas were positive for PLIN1, 97.3% of 30 myxoid liposarcomas were positive for PLIN1, 72.7% of 13 pleomorphic liposarcomas were positive for PLIN1, and all 15 lipomas or angiolipomas were positive for PLIN1. The gene discussed is PLIN1; the disease is myxoid liposarcoma.