Senda et al., used a model of allergic contact dermatitis to study the role of HMGB1 in keratinocytes and observed an exacerbation of skin inflammation in mice in which the HMGB1 gene was specifically deleted in keratinocytes, indicating an anti-inflammatory function of nuclear HMGB1 in keratinocytes [11]. The gene discussed is HMGB1; the disease is allergic contact dermatitis.