FOXP3 and systemic lupus erythematosus: To shed new light on the molecular mechanism underlying the development of SLE, the present study aimed to realize the probable association of IVS9+459/rs2280883 (T>C) and −2383/rs3761549 (C>T) Foxp3 polymorphisms and also the association of the expression of Foxp3 with SLE through in vitro and machine-learning methods.