Regarding the association of rs3761549 (C>T) polymorphism with SLE risk factors such as antinuclear antibody (ANA), anti-double-stranded DNA (anti-dsDNA), complement (C3/C4), and white blood cell count (WBC), only a significant relationship was found between CT-genotype carriers and anti-dsDNA (Table 4). The gene discussed is C4A; the disease is systemic lupus erythematosus.