However, the general trend that emerged from it was that clinically, HCC in F0 liver (1) was not associated with abnormal liver function, (2) did not show elevated AFP, (3) showed a high frequency of metabolic disease (31%), and, histologically, (4) HCC appeared as a single, large, encapsulated lesion of well-to-moderate differentiated tumor. The gene discussed is AFP; the disease is metabolic disease.