NPPB and congestive heart failure: Similarly, Bayes-Genis et al. [78] showed that among ambulatory patients with CHF, those with elevated levels of both sST2 and NT-proBNP had a markedly increased risk (HR 6.38, 95% CI 4.67–9.25, p < 0.001), again indicating that the assessment of both sST2 and NT-proBNP is more effective in identifying a high-risk subgroup than individual assessments of either biomarker.