TNF and pulmonary embolism: In our previous study, bioinformatics methods were employed to analyze multiple key genes involved in the pathogenesis of pulmonary embolism, demonstrating that CCL2, CXCL10, tumor necrosis factor (TNF), Retnla, tissue factor pathway inhibitor 2 (TFPI2), and cytochrome P450 family 1 subfamily A1 (CYP1A1) play roles in the pathogenesis of pulmonary embolism, with chemokine signal transduction, the chemokine activity pathway, and inflammatory reactions all related to the occurrence of pulmonary embolism [15,16,17].