GATA4 and coronary artery disorder: Indeed, from transgenic mice studies, it is known that CHD severity and the spectrum of defects resulting from a pathogenic mutation is strongly dependent on the genetic background (e.g., 24% of C57BL6/J mice and 70% of FVB mice carrying a Gata4 mutation showed no phenotype in a study by Rajagopal et al. [29]).