TARDBP and proteostasis deficiencies: One target of particular therapeutic interest is Nuclear enriched abundant transcript 1 (NEAT1) (Figure 3), which plays a role in mediating nuclear retention of TAR DNA-binding protein 43 (TDP-43) and is potentially protective in certain proteinopathies [163,164,165,166,167,168] involving aberrant protein aggregates comprising tau, amyloid-β, and α-synuclein.