The observation that WNT5A expression in colon cancer is regulated at the transcriptional level [24], in contrast to breast cancer and hepatocellular carcinoma, where it is regulated at the translational level [1,2], made it possible for us to correlate WNT5A and LGR5 expression not only at the protein level but also at the mRNA level in the larger and publicly available TCGA-COAD cohort. Here, LGR5 is linked to malignant colon neoplasm.