RSPO3 and malignant colon neoplasm: Based on the present observations of how WNT5A signaling relates to and regulates LGR5 and RSPO3 expression levels and our previous observation that Foxy5 downregulates DCLK1 in colon cancer tissues in a xenograft mouse model [15], we decided to characterize DCLK1 expression, and in particular its relation to WNT5A expression in three different colon cancer cohorts.