CD4 and mycosis fungoides: The typical immunophenotype of patch-stage MF is ßF1+/CD3+/CD4+/CD8−/TIA-1−, usually with a proportion of reactive CD8+ lymphocytes; about 10% of cases may present either a true cytotoxic phenotype (ßF1+/CD3+/CD8+/CD4−/TIA-1+), or a gamma-delta phenotype (ßF1−/CD3+/CD56+/TIA-1+) [1,32,33,34].