This variability arises because the distribution of the pattern of the infiltrate may differ, leading to several histopathological variants designated with alphabet letters from A to I. In addition to common features, such as the presence of large atypical lymphocytes and the expression of CD30, each histopathological variant of LyP may resemble either a reactive skin condition (e.g., Type A: arthropod reaction) or another lymphoma (e.g., Type B: MF; Type C: ALCL; Type D: aggressive epidermotropic CD8+ cytotoxic TCL; Type E: aggressive “angiotropic” lymphomas). Here, TNFRSF8 is linked to lymphoma.