TLR4 and colorectal carcinoma: A large study conducted on a group of advanced and metastatic CRC revealed that specific TLR variants, such as TLR4 Asp299Gly, TLR4 Thr399Ile, TLR9 T1237C, TLR9 T1486C, and TLR2 -196 to -174 del/del homozygous genotypes, were significantly associated with CRC.