AKT1 and tuberculosis: Patients with active TB exhibit activation of the P13K/AKT/mTOR pathway in CD14+ monocytes, as indicated by a study that found increased levels of the phosphorylated pathway targets p70 ribosomal S6 kinase (p70-S6K) and eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) through Western blotting [27].