TH and Parkinson disease: Taurine (150 mg/kg) treatment attenuated paraquat and the maneb-induced loss of TH-positive neurons in the noradrenergic locus coeruleus; inhibited microglial activation, M1 polarization, and the release of proinflammatory cytokines; and abrogated microglial NADPH oxidase activation and oxidative damage in PD mice.