NFE2L2 and diabetes mellitus: Altogether, these results demonstrate that the ImpL2-mediated reduction in IIS signaling in cncCOE flies, as part of build-in negative feedback loops aiming to suppress cncC/Nrf2 activity [19], plays an important role in the manifestation of several diabetes-like metabolic alterations after prolonged cncC/Nrf2 overactivation.