We recently showed [19] that the sustained inducible overexpression (OE) of cap’n’collar isoform C (cncC; the ortholog of mammalian Nrf2) in adult Drosophila suppresses IIS, leading to metabolic deregulation and diabetes-like phenotypes; we also found that ImpL2 gene expression is directly regulated by cncC/Nrf2 [19]. Here, NFE2L2 is linked to diabetes mellitus.