Based on our findings on the role played by SMYD3 in the modulation of AMPK-mTOR signaling balance, it can be speculated that SMYD3 activity on AMPK might promote the downregulation of PD-L1, thereby suggesting a role in the modulation of AMPK and mTOR signaling balance in the context of cancer immunosurveillance. This evidence concerns the gene CD274 and cancer.