According to these data, mutations in PIK3CA have been reported in approximately 1/5 patients with myxoid/round cell liposarcoma [26,38]; alterations in NF1 are found in a subset of patients with MPNST, myxofibrosarcoma, and pleomorphic liposarcoma [26,30], and TP53 mutations are frequent in dedifferentiated liposarcoma (DDLPS), leiomyosarcoma and myxofibrosarcoma [12,28], and alterations in homologous recombination deficiency (HRD) genes in leiomyosarcoma [12]. This evidence concerns the gene TP53 and leiomyosarcoma.