GFAP and glaucoma: The analysis of the ASC speck formation to detect retinal cell types that activate inflammasomes in the chronic OHT-induced glaucoma showed that the RBPMS+ RGCs accounted for the majority of ASC-citrine-positive cells (≥60%) in retinal wholemounts, whereas the second most common type were GFAP+ astrocytes (~25%), and only a minor (<10%) proportion of ASC specks co-localized with retinal blood vessels (Figure 10E–G).