As inflammatory cytokines (IL-1, IL-6, IL-8, TNF-α) are induced by the infection of CF lungs [56,91,92,93], additional studies, e.g., bulk RNA sequencing, may reveal new inflammatory pathways that are upregulated by P. aeruginosa during prolonged infection of HBE. This evidence concerns the gene CXCL8 and cystic fibrosis.