Currently, LHON is commonly thought to be caused by a mutation present from G to A, at position 11,778 on the granulosa chromosome, leading to abnormalities in the MT-ND4 gene [43], of which, 11,778 mutations are very common, accounting for 90% of reported cases in Asian patients and 70% of cases in European patients. This evidence concerns the gene MT-ND4 and Leber hereditary optic neuropathy.