LHON stands out as the most prevalent neuropathy arising from primary mitochondrial mutations, specifically at the m.11778G>A/MT-ND4, m.3460G>A/MT-ND1, and m.14484T>C/MT-ND6 loci within the mitochondrial genes. This evidence concerns the gene MT-ND4 and Leber hereditary optic neuropathy.