According to the Enrichr “ENCODE and ChEA Consensus TFs from ChIP-X” library, IRF (IRF1, IRF8), REST, FOSL2, SRF, and RELA (member of NF-kB family) are outlined as common regulators of activated human host genes in the process of VV-GMCSF-Lact infection, whereas NFY (NFYA and NFYB) and E2F (E2F1, E2F4 and E2F6) transcription factor control sets of human DEGs are suppressed following infection with the virus (Table S4). The gene discussed is E2F4; the disease is infection.