IRF1 and infection: According to the Enrichr “ENCODE and ChEA Consensus TFs from ChIP-X” library, IRF (IRF1, IRF8), REST, FOSL2, SRF, and RELA (member of NF-kB family) are outlined as common regulators of activated human host genes in the process of VV-GMCSF-Lact infection, whereas NFY (NFYA and NFYB) and E2F (E2F1, E2F4 and E2F6) transcription factor control sets of human DEGs are suppressed following infection with the virus (Table S4).